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Small molecule · Energy & Performance Track
What it is
5-Amino-1MQ is a small-molecule inhibitor of NNMT — an enzyme that, when overactive, consumes NAD+ precursors and drives white adipose tissue accumulation. Blocking NNMT does two useful things at once: it preserves NAD+ levels and it reduces the cellular bias toward fat storage. Newer to the protocol world but rapidly earning its place.
Who it’s for
Patients targeting body composition, metabolic flexibility, and longevity simultaneously. The man whose lifts are dialed in but whose midsection won’t budge despite the work. Pairs naturally with NAD+ and MOTS-c for a stacked Energy & Performance Track approach.
How it works
By inhibiting NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM levels — both of which the body uses for energy production, repair, and methylation. Downstream effects include improved fat metabolism, better insulin handling, and more available cellular currency for everything else the protocol asks of you. Stay on track and reassess at 30 days.